Honestly, that makes no sense.
The PS3 can handle a 1TB internal HDD (or SSD) without any problem – and even more depending on the model and setup. Why would you even need more space than that on a PS3?
Replacing the Blu-ray drive with a hard drive is extremely impractical. The BD drive in the PS3 is cryptographically paired and programmed to the motherboard. Even replacing it with another original drive requires remarrying it, dumping the ERK, and doing quite a bit of work. It's not a simple plug-and-play swap.
Turning that space into an HDD bay would be extremely complicated – and for what purpose? You can already install a 1TB+ internal drive, and you can also connect external storage over USB.
Enjoy the Blu-ray drive and what the PS3 offers. Storage is not really the limitation here.