There's been some major changes on the ps3 front. rebug 4.65-4.70 all have these updated ps2 changes. An option would be as described to go to rebug.me, and get the FULL rebug toolbox
and switch your ps2 emulator.
What I did for ps2 to work perfectly (including wireless)
1. Installed ps2 classics iso launcher rebug edition
2. Used psnpatch to activate the rap file
2. Converted one of my iso games to classic and placed in proper directory (see instructions on rebug.me)
3. Found a couple blamk vme files and copied them over to proper directory
4. launched the ps2 classics ONCE to set it up, then exited.
5. Used webman to load my ps2 iso game
6. Used classics launcher to launch it.
Works perfect every time. I can use the straight iso now as well, but require the controller to be connected.
Truly flawless iso playback on ps2 was lost at 4.5+ firmwares. This is the closest we've come since.
you are going to HAVE TO use reactpsn or psnpatch to activate the ps2 classics to get this to work. Or downgrade to a 4.46 release, which was before SONY messed it all up